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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often focused on practical aspects of the study design, such as the recruitment and consent process as well as adherence to the use of commonly available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However excessive heterogeneity could result in issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually ordered by policymakers and practitioners in order to guide their decisions. They can be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used in lieu for the use of explanation studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, and monitoring.
프라그마틱 공식홈페이지 of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatics. However, it is important to remember that the majority of these trials were conducted in primary care settings.